Since 1996 Clinical Trials of DEBACTEROL® have been conducted by Dr. Nelson Rhodus, DMD MPH, Director of Oral Medicine/Diagnosis, University of Minnesota, School of Dentistry. Studies comparing the effectiveness of DEBACTEROL® with the effectiveness of Kenalog in Orabase® in the treatment of Recurrent Aphthous Stomatitis have been done and results have been published. 

Additional studies are underway to evaluate the histology of oral mucosa that has been treated repeatedly with DEBACTEROL®.